Endocrine Abstracts

Introduction: The World Health Organisation (WHO) states that in an iodine sufficient population <3% of neonatal TSH values will exceed 5 mU/l. In Belgium and Wales 2.6 and 1.5% of values were above 5 mU/l respectively.Methods: Neonatal TSH (neoTSH) levels (AutoDELFIA fluoroimmunoassay, 2006–2013, Scotland) were analysed for prevalence of high value according to cut-off, season and feeding mode (IBM SPSS 22).Results: Out o...

Background: In Scotland median age at notification with elevated capillary (c) TSH (>25 initially or >8 μ/l on repeat testing) is 10 (range 3–35) days. If cTSH elevation is >100 μ/l decompensated hypothyroidism (moderate: free (f) T4 5 −<10, severe: <5 pmol/l) is likely and thyroxine treatment should start without delay. If TSH elevation is mild the clinician may prefer to wait for venous (v) fT4 result and observe the infant’s pro...

Background: In adults, hypoparathyroidism is a rare, but recognised complication of radioactive Iodine therapy. Hypothyroidism has been reported in neonates who have been exposed to Iodine131 in-utero, however, only one case of neonatal hypoparathyroidism secondary to maternal Iodine131 therapy has been described in the literature. To our knowledge this is the first case in the UK.Case presentation: A 27-year-old woman received two ...

IntroductionParaneoplastic hypercalcemia is extremely rare in the pediatric population, requiring urgent treatment. Pediatric malignancy-related hypercalcemia (PMRH) has been associated with rhabdomyosarcoma (RMS). Hypercalcemia with elevated parathyroid hormone (PTH), ectopic PTH secretion, is rarer (< 1% of cases). Reports of the use of Zoledronic Acid (ZA) as a second line bisphosphonate are limited. The monoclonal antibody, Denosumab, which inhib...

Introduction: Iodine is essential for thyroid hormones synthesis, and fetal/infant neurodevelopment. There is increasing evidence of iodine insufficiency among British women. The MABY study is a longitudinal cohort study assessing the iodine and thyroid status of pregnant women and their offspring.Methods: Healthy women were recruited (target 697 mother/infant pairs) from antenatal clinics at gestational week (GW) 28±1. Blood and urine were collecte...